S-2-溴-2-苯基乙酸合成路线 （共 16 条）
反应条件
(i) HN(SiMe3)2, CHCl3, (ii) /BRN= 4946351/, DCC, CH2Cl2, (iii) hexamethylentetramine; Multistep reaction;
参考文献
Kajfez; Kovac; Mihalic; et al.
Journal of Heterocyclic Chemistry, 1976 , vol. 13, # 3 p. 561 - 566
反应条件
1: With (R)-BINOL-SnCl4 in dichloromethane; toluene
T=-78°C; enantioselective protonation; 1 h;
2: With hydrogenchloride in dichloromethane; toluene
Hydrolysis; Further stages. Title compound not separated from byproducts.;
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
lipase from carica papaya latex in decane
pH=8.5; Resolution of racemate; SolventConcentrationReagent/catalyst; enantioselective reaction;
参考文献
Rivera, Ivanna; Mateos, Juan Carlos; Marty, Alain; Sandoval, Georgina; Duquesne, Sophie
Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5523 - 5526
反应条件
1.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C
1.2: tetrahydrofuran / 5 h / -78 - 20 °C
2.1: (R)-BINOL-SnCl4 / toluene; CH2Cl2 / 1 h / -78 °C
2.2: aq. HCl / toluene; CH2Cl2
View Scheme
参考文献
Nakamura, Shingo; Kaneeda, Masanobu; Ishihara, Kazuaki; Yamamoto, Hisashi
Journal of the American Chemical Society, 2000 , vol. 122, # 34 p. 8120 - 8130
反应条件
L-prolinol-derived ionic liquid in phosphate buffer
T=20°C; pH=7.5;
参考文献
Rizvi, Syed Asad Ali; Shamsi, Shahab A.
Analytical Chemistry, 2006 , vol. 78, # 19 p. 7061 - 7069
反应条件
water; Candida rugosa lipase in cyclohexane
T=45°C; 2 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Wang, Pei-Yun; Wu, Chia-Hui; Ciou, Jyun-Fen; Wu, An-Chi; Tsai, Shau-Wei
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 1-2 p. 113 - 119
反应条件
water; Candida rugosa lipase in cyclohexane
T=45°C; 4 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Wang, Pei-Yun; Wu, Chia-Hui; Ciou, Jyun-Fen; Wu, An-Chi; Tsai, Shau-Wei
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 1-2 p. 113 - 119
反应条件
1: With 2,4,4,6-tetrabromo-2,5-cyclohexadien-1-one; triphenylphosphine in dichloromethane
T=0 - 10°C; 1.5 h;
2: With sodium hydrogencarbonate in water
参考文献
Matveeva; Podrugina; Sandakova; Zefirov
Russian Journal of Organic Chemistry, 2004 , vol. 40, # 10 p. 1469 - 1472
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether
T=45°C; 12 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Wang, Pei-Yun; Wu, Chia-Hui; Ciou, Jyun-Fen; Wu, An-Chi; Tsai, Shau-Wei
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 1-2 p. 113 - 119
反应条件
sulfuric acid; potassium bromide; sodium nitrite
1.) 0 deg C, 3 h (addition) than 1 h, 2.) r.t., overnight;
参考文献
Balboni, Gianfranco; Salvadori, Severo; Marastoni, Mauro; Tomatis, Roberto; Borea, Pier A.; Bianchi, Clementina
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1645 - 1652
