(2E)-3-[3-(三氟甲基)苯基]丙烯酰氯合成路线 （共 3 条）
反应条件
1: 92 percent / NH4OH / dioxane / 0 °C 2: 89 percent / H2 / Pd/C / methanol / 16 h / 20 °C 3: 65 percent / LAH / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683
反应条件
1: triethylamine / CHCl3
2: POCl3 / 0.5 h / 100 - 110 °C
3: 99.4 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath
4: SOCl2 / 1 h / Heating
5: NaBH4, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min
View Scheme
参考文献
Meguro; Tawada; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2840 - 2851
反应条件
1: 92 percent / NH4OH / dioxane / 0 °C
2: 89 percent / H2 / Pd/C / methanol / 16 h / 20 °C
View Scheme
参考文献
Wang, Xin; Chen, Ying; Crockett, Richard; Briones, Jorge; Yan, Tony; Orihuela, Carlos; Zhi, Benxin; Ng, John
Tetrahedron Letters, 2004 , vol. 45, # 45 p. 8355 - 8358
