1-(2-二苯甲基氧基-乙基)-哌嗪合成路线 （共 10 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 1 h;
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
参考文献
Sankyo Company Limited
Patent: EP549364 A1, 1993 ;
反应条件
potassium carbonate in diethyl ether; toluene
参考文献
Rosenthal, Sandra J.; Tomlinson, Ian D.; Kippeny, Tadd
Patent: US2005/192430 A1, 2005 ;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6172085 B2, 2001 ;
US 6172085 B1
参考文献
Morren et al.
Industrie Chimique Belge, 1954 , vol. 19, p. 1176,1181
反应条件
1: H2SO4 / toluene / Heating
2: K2CO3 / toluene / 12 h / Heating
View Scheme
参考文献
Lewis, David B.; Matecka, Dorota; Zhang, Ying; Hsin, Ling-Wei; Dersch, Christina M.; Stafford, David; Glowa, John R.; Rothman, Richard B.; Rice, Kenner C.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 24 p. 5029 - 5042
反应条件
potassium carbonate in toluene
36 h; Heating;
参考文献
Matecka, Dorota; Rothman, Richard B.; Radesca, Lilian; De Costa, Brian R.; Dersch, Christina M.; Partilla, John S.; Pert, Agu; Glowa, John R.; Wojnicki, Francis H. E.; Rice, Kenner C.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 24 p. 4704 - 4716
反应条件
1.1: dichloromethane / 1 h / 20 °C
2.1: iodine; triphenylphosphine / dichloromethane / 20 h
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
3.2: 6 h / 110 °C
4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
1.2: 6 h / 110 °C
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
反应条件
1.1: iodine; triphenylphosphine / dichloromethane / 20 h
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
2.2: 6 h / 110 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
