4,4-二甲氧基乙酰乙酸甲酯合成路线 （共 17 条）
反应条件
methyl acetate; sodium methylate; benzene
参考文献
Journal of the American Chemical Society, , vol. 78, p. 4161,4162
参考文献
Journal of the American Chemical Society, , vol. 70, p. 14,18
参考文献
Ancos, B. De; Delgado, F.; Martin, M. R.
Anales de Quimica, 1995 , vol. 91, # 5-6 p. 413 - 420
反应条件
in methanol 24 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 50, # 48 p. 13857 - 13864
反应条件
(i) NaH, (ii) /BRN= 1560557/; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 42, p. 525 - 527
反应条件
192 h; Heating; Yields of byproduct given;
参考文献
Ancos, B. de; Farina, F.; Maestro, M. C.; Martin, M. R.
Anales de Quimica, 1995 , vol. 91, # 1.2 p. 132 - 141
反应条件
1: piperidine / benzene / 5 h / Heating 2: 3 h / 100 - 120 °C View Scheme
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
反应条件
1: piperidine / benzene / 5 h / Heating 2: 3 h / 100 - 120 °C 3: 6N HCl / acetone / 3 h / 20 °C View Scheme
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
反应条件
morpholine; acetic acid
参考文献
Ogawa, Toshihisa; Matsumoto, Keita; Hatayama, Katsuo; Kitamura, Kunihiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 23 p. 3033 - 3040
反应条件
1: piperidine / benzene / 3 h / Heating 2: 51.1 percent / 8.5 h / 95 - 120 °C 3: 95.4 percent / 6 N aq. HCl / acetone / 1 h / Ambient temperature 4: 1.) NH2OH*HCl, NaOAc, 2.) Ac2O / 1.) AcOH, RT, 2.5 h, 2.) AcOH, a) RT, 1.5 h, b) 95 deg C - 100 deg C, 4 h View Scheme
参考文献
Satoh; Ichihashi; Okumura
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3189 - 3201
