4-氨基-1-苄基嘧啶-2-酮合成路线 （共 3 条）
反应条件
tetra(n-butyl)ammonium hydroxide in methanol; N,N-dimethyl-formamide; isopropyl alcohol
T=20°C; 2 h;
参考文献
Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.; Bartolomé-Nebreda, José Manuel; MacDonald, Gregor James; Conde-Ceide, Susana; Jones, Carrie K.; Luz Martín-Martín, María; Tong, Han Min
Patent: US2013/245043 A1, 2013 ;
Location in patent: Paragraph 0527; 0528 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 72 h;
参考文献
AMGEN INC.; BO, Yunxin, Y.; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; SIEGMUND, Aaron, C.; TAMAYO, Nuria, A.; YANG, Kevin
Patent: WO2010/108074 A2, 2010 ;
Location in patent: Page/Page column 58 ;
WO 2010/108074 A2
反应条件
ammonium hydroxide
1.) rt, 17 h, 2.) 100 deg C, 30 min;
参考文献
Helfer II; Hosmane; Leonard
Journal of Organic Chemistry, 1981 , vol. 46, # 23 p. 4803 - 4804
