反应条件
1: 4,6-dichloropyrimidine-2-(methylthio)pyrimidine With Rink-amide derivatised polystyrene resin; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=90°C; Solid phase reaction; substitution;
2: benzylamine With 1-methyl-pyrrolidin-2-one
T=140°C; Solid phase reaction; substitution; 15 h;
3: With water; trifluoroacetic acid in dichloromethane
T=20°C; Solid phase reaction; resin cleavage; 3 h;
参考文献
Guillier, Fabrice; Roussel, Patrick; Moser, Heinz; Kane, Peter; Bradley, Mark
Chemistry - A European Journal, 1999 , vol. 5, # 12 p. 3450 - 3458