1: With 4-methyl-morpholine; p-iodo-benzoic acid chloride in ethylene glycol dimethyl ether T=-15°C; 0.25 h; 2: With sodium tetrahydroborate in ethylene glycol dimethyl ether; water T=-15 - 20°C; 0.25 h; 3: With sodium hydroxide; water in ethylene glycol dimethyl ether
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/108591 A1, 2006 ;
Location in patent: Page/Page column 119 ;
WO 2006/108591 A1