4-溴-5-氯噻吩-2-羧酸合成路线 （共 3 条）
反应条件
anhydrous iron chloride; bromine in acetic acid
T=25°C; 168 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/98104 A1, 2008 ;
Location in patent: Page/Page column 81-82 ;
WO 2008/098104 A1
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide
T=50°C; 10 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/98104 A1, 2008 ;
Location in patent: Page/Page column 177 ;
WO 2008/098104 A1
反应条件
1: 67 percent / Br2, AlCl3 / CHCl3 / 2 h / Heating
2: 1) NaOH, Cl2 / 1) H2O, -10 deg C, 2) 50 deg C
View Scheme
参考文献
Stanetty, Peter; Puschautz, Erhard; Friedbacher, Gernot
Monatshefte fuer Chemie, 1989 , vol. 120, p. 53 - 63
