(3-溴-5-硝基-吡啶-4-基)-乙基-胺合成路线 （共 11 条）
反应条件
bromine; sodium acetate in acetic acid
T=100°C; 18 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/11700 A1, 2005 ;
Location in patent: Page/Page column 121-122 ;
WO 2005/011700 A1
反应条件
in tetrahydrofuran
T=20°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/37198 A2, 2005 ;
Location in patent: Page/Page column 27 ;
WO 2005/037198 A2
反应条件
1: aq. sodium dithionite / ethanol / 60 °C
2: 190 °C
View Scheme
参考文献
Bamford, Mark J.; Bailey, Nicholas; Davies, Susannah; Dean, David K.; Francis, Leann; Panchal, Terence A.; Parr, Christopher A.; Sehmi, Sanjeet; Steadman, Jon G.; Takle, Andrew K.; Townsend, James T.; Wilson, David M.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3407 - 3411
反应条件
hydrogenchloride; SnCl2·2H2O in water
T=20°C; 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/11700 A1, 2005 ;
Location in patent: Page/Page column 122 ;
WO 2005/011700 A1
反应条件
in hydrogenchloride; water
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: hydrogenchloride; water
2: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: hydrogenchloride; water
2: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
3: acetic acid
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: hydrogenchloride; water
2: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
3: acetic acid
4: sodium nitrite
5: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1: hydrogenchloride; water
2: 1,2-dichloro-ethane; 4-methyl-morpholine / dichloromethane; ethyl acetate; water
3: acetic acid
4: sodium nitrite
5: triethylamine; hydroxylamine / 1,4-dioxane; water; methanol
6: hydrogenchloride; sodium hydroxide; dihydrogen peroxide / ethyl acetate; toluene; water; isopropylmagnesium chloride; tetrahydrofuran
View Scheme
参考文献
Cellzome AG
Patent: US2011/70595 A1, 2011 ;
反应条件
1.1: aq. sodium dithionite / ethanol / 60 °C
2.1: 190 °C
3.1: NaNO2; HCl / methanol / 20 °C
3.2: 45 percent / NH2OH; NaOH / methanol / Heating
View Scheme
参考文献
Bamford, Mark J.; Bailey, Nicholas; Davies, Susannah; Dean, David K.; Francis, Leann; Panchal, Terence A.; Parr, Christopher A.; Sehmi, Sanjeet; Steadman, Jon G.; Takle, Andrew K.; Townsend, James T.; Wilson, David M.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3407 - 3411
