2-(4-氨基-1,2,5-噁二唑-3-基)-1-乙基-1H-咪唑并[4,5-c]吡啶-7-醇合成路线 (共 1 条)
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C;
2: With boric acid trimethyl ester in tetrahydrofuran; hexane
T=-78 - 20°C; 1.5 h;
3: With hydrogenchloride; sodium hydroxide; dihydrogen peroxide
more than 3 stages;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/46678 A1, 2005 ;
Location in patent: Page/Page column 85-86 ;
WO 2005/046678 A1