2-氯-4-甲氧基-5-硝基吡啶合成路线 （共 3 条）
反应条件
iron; ammonium chloride in ethanol; water T=80°C; 18 h;
参考文献
WO2013/79495 A1, ;
Page/Page column 59 ;
反应条件
1: tetrahydrofuran / 2 h / 20 °C
2: iron; acetic acid / 50 - 80 °C
3: orthoformic acid triethyl ester / 4 h / 100 °C
View Scheme
参考文献
GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoît Antoine; GENEY, Raphaël Jean Joël; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart
Patent: WO2013/117645 A1, 2013 ;
反应条件
in tetrahydrofuran
T=0 - 20°C;
参考文献
GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoît Antoine; GENEY, Raphaël Jean Joël; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart
Patent: WO2013/117645 A1, 2013 ;
Location in patent: Paragraph 00565 ;
