4,6-二甲基异噻唑并[5,4-b]吡啶-3(2H)-酮合成路线 (共 11 条)
反应条件
potassium permanganate in acetic acid T=3 - 5°C; 1 h;
参考文献
Zawisza; Malinka
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 9 p. 676 - 683
反应条件
sodium hydroxide; dihydrogen peroxide in water reflux then 2 h, room temp.; Yield given;
参考文献
Zawisza; Malinka
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 9 p. 676 - 683
反应条件
1: With sulfuric acid
T=100°C; 4 h;
2: With sodium hydrogencarbonate in water
pH=5 - 6;
参考文献
CHANG, Zee-Fen; HU, Chun-Mei; FANG, Jim-Min; YEH, Ming-Tyng
Patent: WO2012/72019 A1, 2012 ;
Location in patent: Page/Page column 64 ;
WO 2012/072019 A1
反应条件
sulfuric acid
T=100°C; 1 h;
参考文献
Zawisza; Malinka
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 2 p. 124 - 132
反应条件
sulfuric acid
T=100°C; 1 h;
参考文献
Zawisza; Malinka
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 2 p. 124 - 132
反应条件
sulfuric acid
T=100°C; 1 h;
参考文献
Zawisza; Malinka
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 2 p. 124 - 132
反应条件
2: 7.5 g / KOH / ethanol; H2O / 0.25 h
3: 50 percent / conc. H2SO4 (d=1.83) / 1 h / 100 °C
View Scheme
参考文献
Zawisza; Malinka
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 2 p. 124 - 132
反应条件
1: 70 percent / ethanol / Ambient temperature
2: 5percent aq. HCl / 0.25 h / Ambient temperature
View Scheme
参考文献
Malinka; Rutkowska
Farmaco, 1997 , vol. 52, # 10 p. 595 - 601
反应条件
1.1: thiourea / butan-1-ol / 4 h / 118 °C
2.1: sulfuric acid / 4 h / 100 °C
2.2: pH 5 - 6
View Scheme
参考文献
CHANG, Zee-Fen; HU, Chun-Mei; FANG, Jim-Min; YEH, Ming-Tyng
Patent: WO2012/72019 A1, 2012 ;
WO 2012/072019 A1
反应条件
1: aq. NaOH, potassium hexacyanoferrate(III)
2: Ambient temperature
View Scheme
参考文献
Schaper, Wolfgang
Synthesis, 1985 , # 9 p. 861 - 867