3-乙氧基-4-甲氧基苯腈合成路线 （共 13 条）
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 - 5 °C 1.2: 2 h / 0 - 30 °C 2.1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; (S,R)-t-Bu-Josiphos / 2,2,2-trifluoroethanol / 18 h / 50 °C / 4654.46 Torr / |Inert atmosphere 3.1: acetic acid / |Reflux View Scheme
参考文献
Celgene Corporation; Connolly, Terrence J.; Ruchelman, Alexander L.; Yong, Kelvin H.Y.; Zhang, Chengmin
Patent: US2014/81032 A1, 2014 ;
反应条件
hydroxylamine hydrochloride in acetonitrile
T=5 - 84°C; Product distribution / selectivity;
参考文献
CELGENE CORPORATION; SAINDANE, Manohar, T.; GE, Chuansheng
Patent: WO2010/30345 A2, 2010 ;
Location in patent: Page/Page column 10 ;
WO 2010/030345 A2
反应条件
trichlorophosphate in pyridine
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
反应条件
1: formic acid; hydroxylamine hydrochloride; sodium formate / 3 h / 125 °C
2: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
Kumar, Dalip; Patel, Gautam; Vijayakrishnan, Lalitha; Dastidar, Sunanda G.; Ray, Abhijit
Chemical Biology and Drug Design, 2012 , vol. 79, # 5 p. 810 - 818
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Kumar, Dalip; Patel, Gautam; Vijayakrishnan, Lalitha; Dastidar, Sunanda G.; Ray, Abhijit
Chemical Biology and Drug Design, 2012 , vol. 79, # 5 p. 810 - 818
反应条件
acetic anhydride
Heating;
参考文献
Khadse, B. G.; Lokhande, S. R.; Bhamaria, R. P.; Prabhu, S. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 856 - 860
参考文献
Buck; Ide
Journal of the American Chemical Society, 1932 , vol. 54, p. 3302,3308
Journal of the American Chemical Society, 1931 , vol. 53, p. 1912,1914
