3-乙氧基-4-甲氧基苯腈合成路线 （共 13 条）
反应条件
in tetrahydrofuran; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6384080 B1, 2002 ;
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / |Large scale
1.2: 0 - 5 °C / |Large scale
1.3: |Large scale
2.1: toluene-4-sulfonic acid / toluene / |Dean-Stark; |Large scale
2.2: |Large scale
2.3: |Large scale
3.1: hydrogen; 5 palladium on charcoal / methanol / 20 °C / |Large scale
View Scheme
参考文献
Celgene Corporation; Connolly, Terrence J.; Ruchelman, Alexander L.; Yong, Kelvin H.Y.; Zhang, Chengmin
Patent: US2014/81032 A1, 2014 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 5 °C
1.2: 2 h / 0 - 30 °C
2.1: hydrogen; Ru(OAc)2((R)-dm-segphos) / 2,2,2-trifluoroethanol / 18 h / 50 °C / 13689.1 Torr / |Inert atmosphere
View Scheme
参考文献
CELGENE CORPORATION; CONNOLLY, Terrence J.; RUCHELMAN, Alexander L.; LEONG, William W.
Patent: US2013/217919 A1, 2013 ;
