4-(1,3-三唑-4-基)苯胺合成路线 （共 8 条）
反应条件
methanol; palladium on activated charcoal
Hydrogenation;
参考文献
Ochiai et al.
Yakugaku Zasshi, 1939 , vol. 59, p. 462,468; dtsch. Ref. S. 228, 233
Chem.Abstr., 1954 , p. 0 5449
反应条件
1: With hydrogenchloride; SnCl2·2H2O in ethanol; water
2 h; Reflux;
2: With potassium hydroxide in ethanol; water
T=0°C;
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; MAY, John; O'CONNOR, Patrick; RIPKA, William; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85128 A1, 2011 ;
Location in patent: Page/Page column 55 ;
反应条件
1.1: diphosphorus pentasulfide / trans-1,3-dioxane / 1 h / Reflux; Inert atmosphere
1.2: 1 h / Reflux
2.1: ammonium chloride / iron / ethanol / 2 h / Reflux
View Scheme
参考文献
EPIZYME, INC.; CHESWORTH, Richard; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; PATANE, Michael, A.
Patent: WO2012/82436 A2, 2012 ;
WO 2012/082436 A2
反应条件
hydrazine hydrate in ethanol
0.75 h; Heating;
参考文献
Peet, Norton P.; Sunder, Shyam
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 593 - 595
反应条件
1.1: ethanol / 19 h / 80 °C
2.1: hydrogenchloride; SnCl2·2H2O / ethanol; water / 2 h / Reflux
2.2: 0 °C
View Scheme
参考文献
SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-Michel; MAY, John; O'CONNOR, Patrick; RIPKA, William; PINKERTON, Anthony; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie
Patent: WO2011/85128 A1, 2011 ;
反应条件
1: Nitrierung
2: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Erlenmeyer et al.
Helvetica Chimica Acta, 1947 , vol. 30, p. 2058,2061
参考文献
Kulkarni; Fernandez; Patel; Bellare; Deliwala
Journal of pharmaceutical sciences, 1969 , vol. 58, # 7 p. 852 - 857
反应条件
1: piperidine; P2S5
2: Nitrierung
3: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Erlenmeyer et al.
Helvetica Chimica Acta, 1947 , vol. 30, p. 2058,2061
