1: 99 percent / pyridine / CHCl3 / Ambient temperature 2: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 3: t-BuOK / tetrahydrofuran / Ambient temperature 4: dimethylformamide / 80 °C 5: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 6: 68.7 percent / pyridine / 72 h / Ambient temperature 7: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 8: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 9: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 10: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 99 percent / pyridine / CHCl3 / Ambient temperature 2: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 3: t-BuOK / tetrahydrofuran / Ambient temperature 4: dimethylformamide / 80 °C 5: 100 percent / pyridine / CHCl3 / 2 h / Ambient temperature 6: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 7: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature View Scheme

1: 99 percent / pyridine / CHCl3 / Ambient temperature 2: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 3: t-BuOK / tetrahydrofuran / Ambient temperature 4: dimethylformamide / 80 °C 5: 75.9 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature 6: 93.8 percent / H2 / 10percent Pd/C / tetrahydrofuran / 0.25 h View Scheme