sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane T=40°C; 16.5 h;

potassium carbonate in propan-1-ol T=100°C; 17.25 - 23 h; Product distribution / selectivity;

palladium diacetate; sodium t-butanolate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in 1,4-dioxane T=90°C; Buchwald-Hartwig Coupling; 16 h; Inert atmosphereSchlenk technique;

1: N-methyl-2-(methylamino)ethylamine; caesium carbonate; copper(l) iodide / dimethyl sulfoxide / 4 h / 110 °C 2: tris-(dibenzylideneacetone)dipalladium(0); N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; sodium t-butanolate / toluene / 110 °C / |Inert atmosphere 3: trifluoroacetic acid / dichloromethane / 2 h View Scheme

1: tris-(dibenzylideneacetone)dipalladium(0); N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; sodium t-butanolate / toluene / 110 °C / |Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 2 h View Scheme

1: N-iodo-succinimide; acetic acid; sodium sulfite / 1 h / 20 - 80 °C 2: N-methyl-2-(methylamino)ethylamine; caesium carbonate; copper(l) iodide / dimethyl sulfoxide / 4 h / 110 °C 3: tris-(dibenzylideneacetone)dipalladium(0); N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; sodium t-butanolate / toluene / 110 °C / |Inert atmosphere 4: trifluoroacetic acid / dichloromethane / 2 h View Scheme

trifluoroacetic acid in dichloromethane 2 h;