1: 1.) hydrogen chloride gas, 2.) water / 1.) ether, 45 min, 2.) 40 deg C
2: 92 percent / potassium carbonate / acetone / 5 h / Heating
3: 78 percent / lithium aluminium hydride / diethyl ether / 3 h / Ambient temperature
View Scheme
参考文献
Barber, Jill; Staunton, James
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1685 - 1689
potassium carbonate in N,N-dimethyl-formamide
T=95°C; 25 h;
参考文献
Moormann, Alan E.; Pitzele, Barnett S.; Jones, P. H.; Gullikson, Gary W.; Albin, David; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 614 - 626