1,3-二甲基-2-碘苯合成路线 （共 73 条）
反应条件
1: lithium; diethyl ether / anschliessend Behandeln mit Acetaldehyd 2: K2cr2O7; aqueous H2SO4 View Scheme
参考文献
Schwartzman; Corson
Journal of the American Chemical Society, 1954 , vol. 76, p. 781,783
反应条件
1: 82 percent / 60percent sodium hydride, CuI / hexamethylphosphoric acid triamide / 17 h / 105 °C 2: 47 percent / N-bromosuccinimide / CCl4 / 46 h / 15 °C / Irradiation View Scheme
参考文献
Fujihara,H.; Chiu,J.; Furukawa,N.
Journal of the American Chemical Society, 1988 , vol. 110, p. 1280
反应条件
diethyl ether; lithium
anschliessend Behandeln mit Acetaldehyd;
参考文献
Schwartzman; Corson
Journal of the American Chemical Society, 1954 , vol. 76, p. 781,783
反应条件
PEPPSI-IPr catalyst; caesium carbonate in chlorobenzene
T=80°C; P=760.051 Torr; 24 h; Inert atmosphere;
参考文献
O'Keefe, B. Michael; Simmons, Nicholas; Martin, Stephen F.
Tetrahedron, 2011 , vol. 67, # 24 p. 4344 - 4351
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate in chlorobenzene
T=80°C; Suzuki cross-coupling; P=760.051 Torr; 24 h; Inert atmosphere;
参考文献
O'Keefe, B. Michael; Simmons, Nicholas; Martin, Stephen F.
Tetrahedron, 2011 , vol. 67, # 24 p. 4344 - 4351
反应条件
1.1: 94 percent / Pd(OAc)2; Et3N; (2-MeC6H4)3P / acetonitrile / 24 h / Heating
2.1: 99 percent / 1 M aq. NaOH / dioxane / 2 h / 20 °C
3.1: H2 / 10 percent Pd/C / ethyl acetate / 70 °C / 3040 Torr
4.1: Et3N; DCC; HOBt / dimethylformamide / 5 h / 0 - 20 °C
5.1: conc. HCl / 8 h / Heating
5.2: H2O / pH 4 - 6
View Scheme
参考文献
Sasaki, Yusuke; Hirabuki, Mariko; Ambo, Akihiro; Ouchi, Hidekazu; Yamamoto, Yutaka
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 3 p. 327 - 329
反应条件
1: diphenylphosphine oxide With cupric triflate; 1,1,3,3-tetramethyldisiloxane in toluene
T=100°C; 10 h; Inert atmosphere;
2: 2,6-dimethylphenyl iodide With caesium carbonate; N-methyl-2-(methylamino)ethylamine in toluene
T=20 - 110°C; Inert atmosphere;
参考文献
Li, Yuehui; Das, Shoubhik; Zhou, Shaolin; Junge, Kathrin; Beller, Matthias
Journal of the American Chemical Society, 2012 , vol. 134, # 23 p. 9727 - 9732
反应条件
bis-triphenylphosphine-palladium(II) chloride; PPh3 gold(I) chloro complex; triethylamine in N,N-dimethyl-formamide
T=80°C; Sonogashira type cross-coupling; 1 h; Inert atmosphere;
参考文献
Panda, Biswajit; Sarkar, Tarunk.
Synthesis (Germany), 2013 , vol. 45, # 6 art. no. SS-2012-Z0931-OP, p. 817 - 829
反应条件
copper(l) iodide; [Pt(PPh3)4] in N,N-dimethyl-formamide
T=120°C; 14 h;
参考文献
Oh, Chang Ho; Reddy, V. Raghava
Synlett, 2004 , # 12 p. 2091 - 2094
反应条件
PEPPSITM-IPr; caesium carbonate in N,N-dimethyl acetamide
T=80°C;
参考文献
O'Keefe, B. Michael; Simmons, Nicholas; Martin, Stephen F.
Tetrahedron, 2011 , vol. 67, # 24 p. 4344 - 4351
