1,3-二甲基-2-碘苯合成路线 （共 73 条）
参考文献
Cao, Derong; Schollmeyer, Dieter; Meier, Herbert
European Journal of Organic Chemistry, 1999 , # 4 p. 791 - 795
反应条件
1: lithium; diethyl ether / anschliessend Behandeln mit Acetaldehyd
2: activated Al2O3 / 270 - 280 °C / 10 Torr
3: platinum; ethanol / Hydrogenation
View Scheme
参考文献
Schwartzman; Corson
Journal of the American Chemical Society, 1954 , vol. 76, p. 781,783
反应条件
copper(l) iodide; tetra(n-butyl)ammonium hydroxide; sulfur in water
T=40°C; 24 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Xu, Hua-Jian; Liang, Yu-Feng; Cai, Zhen-Ya; Qi, Hong-Xia; Yang, Chun-Yan; Feng, Yi-Si
Journal of Organic Chemistry, 2011 , vol. 76, # 7 p. 2296 - 2300
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 60 °C / Inert atmosphere
2: methanol; potassium carbonate / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
Jahier, Claire; Zatolochnaya, Olga V.; Zvyagintsev, Nickolay V.; Ananikov, Valentine P.; Gevorgyan, Vladimir
Organic Letters, 2012 , vol. 14, # 11 p. 2846 - 2849
反应条件
copper; potassium carbonate in nitrobenzene
48 h; Heating;
参考文献
Hayes, Kathryn S.; Nagumo, Mark; Blount, John F.; Mislow, Kurt
Journal of the American Chemical Society, 1980 , vol. 102, # 8 p. 2773 - 2776
反应条件
bis-triphenylphosphine-palladium(II) chloride; cesium fluoride in N,N-dimethyl-formamide
T=80°C; Suzuki-Miyaura cross-coupling; 2 h; Inert atmosphere;
参考文献
PraveenGanesh, Nageswaran; Chavant, Pierre Yves
European Journal of Organic Chemistry, 2008 , # 27 p. 4690 - 4696
反应条件
magnesium
1.) ether, 2.) ice-bath, 4 h; Yield given. Multistep reaction;
参考文献
Hawkins, David G.; Meth-Cohn, Otto
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , p. 2077 - 2087
反应条件
PEPPSITM-IPr; caesium carbonate in chlorobenzene
T=80°C; 24 h;
参考文献
O'Keefe, B. Michael; Simmons, Nicholas; Martin, Stephen F.
Tetrahedron, 2011 , vol. 67, # 24 p. 4344 - 4351
反应条件
n-butyllithium in pentane
Ambient temperature;
参考文献
Wehman, Erik; Jastrzebski, Johann T. B. H.; Ernsting, Jan-Meine; Grove, David M.; Koten, Gerard van
Journal of Organometallic Chemistry, 1988 , vol. 353, p. 133 - 144
反应条件
palladium on activated charcoal; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=80°C; 20 h; Autoclave;
参考文献
Yu, Bo; Zhao, Yanfei; Zhang, Hongye; Xu, Jilei; Hao, Leiduan; Gao, Xiang; Liu, Zhimin
Chemical Communications, 2014 , vol. 50, # 18 p. 2330 - 2333
