sodium hydroxide in water; acetone T=20°C; 48 h; Product distribution / selectivity;

1: sodium hydroxide / water; acetone 2: potassium phosphate; copper(l) iodide / N-(2-cyanophenyl)pyridine-2-carboxamide / acetonitrile; dimethyl sulfoxide / 16 h / 60 °C / Inert atmosphere View Scheme

1: With sodium hydroxide; sodium hypochlorite; sodium iodide in methanol T=-2 - 2°C; 2: With hydrogenchloride; water in methanol pH=3; Product distribution / selectivity;

1: sodium hydroxide / water; acetone 2: potassium phosphate; copper(l) iodide / N-(2-cyanophenyl)pyridine-2-carboxamide / acetonitrile; dimethyl sulfoxide / 16 h / 60 °C / Inert atmosphere 3: potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0); (Me)CgPPh / water; tetrahydrofuran / 2.5 h / 65 °C / Inert atmosphere 4: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere 5: potassium phosphate / tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos / tetrahydrofuran / 20 h / 20 - 90 °C / Inert atmosphere View Scheme