(S)-3-氯-1,2-丙二醇合成路线 （共 25 条）
反应条件
1: 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate With lithium tert-pentoxide in tetrahydrofuran T=-15°C; 2: (S)-1-chloro-2,3-dihydroxypropane With potassium tert-butylate in tetrahydrofuran T=-25 - 10°C;
参考文献
Gordeev, Mikhail F.; Patel, Dinesh V.; Barbachyn, Michael R.; Gage, James R.
Patent: US2003/13737 A1, 2003 ;
参考文献
RSTECH CORPORATION
Patent: WO2006/19202 A1, 2006 ;
Location in patent: Page/Page column 9 ;
反应条件
hydrogenchloride; N,N-di-methylaminopyridine; potassium carbonate; triethylamine in water
参考文献
Daiso Co., LTd.
Patent: US5965753 A1, 1999 ;
反应条件
1: (S)-1-chloro-2,3-dihydroxypropane With potassium phosphate in dichloromethane 3 h; Reflux; 2: With triethylamine in dichloromethane T=0°C; 1 h; 3: 3-nitro-benzenesulfonyl chloride in dichloromethane T=0 - 25°C; 1 h;
参考文献
Dittrich, Torsten; Hanekop, Nils; Infed, Nacera; Schmitt, Lutz; Braun, Manfred
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1700 - 1704
反应条件
1: (S)-1-chloro-2,3-dihydroxypropane With potassium phosphate in dichloromethane 3 h; Reflux; 2: With triethylamine in dichloromethane T=0°C; 1 h; 3: 3-nitro-benzenesulfonyl chloride in dichloromethane T=0 - 25°C; 1 h;
参考文献
Dittrich, Torsten; Hanekop, Nils; Infed, Nacera; Schmitt, Lutz; Braun, Manfred
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1700 - 1704
