2,3-二氢吡啶并[2,3-d][1,3]噁唑-2-酮合成路线 （共 30 条）
反应条件
chlorine in N,N-dimethyl-formamide Ambient temperature;
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
反应条件
1: 90 percent / Br2 / dimethylformamide / 2 h / 20 °C 2: 94 percent / aq. sodium hydroxide / 8 h / Heating View Scheme
参考文献
Qian, Jian-Qiang; Yan, Pu-Cha; Che, Da-Qing; Zhou, Qi-Lin; Li, Yuan-Qiang
Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1528 - 1531
反应条件
sulfuric acid; nitric acid T=-5 - 20°C; 60 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION; SCHUMACHER, Richard, A.; TEHIM, Ashok; XIE, Wenge
Patent: WO2010/24980 A1, 2010 ;
Location in patent: Page/Page column 103 ;
反应条件
1: Cl2 / dimethylformamide / Ambient temperature 2: H2O View Scheme
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
反应条件
1: Cl2 / dimethylformamide / Ambient temperature 2: H2O 3: SOCl2 / CHCl3 4: acetone / 4 h / 35 °C View Scheme
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
反应条件
1: H2O / 1 h 2: SOCl2 / CHCl3 3: acetone / 4 h / 35 °C View Scheme
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
反应条件
sodium ethanolate 1.) EtOH, RT, 1 h, 2.) DMF, 110 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Flouzat, Christine; Bresson, Yvette; Mattio, Anny; Bonnet, Jacqueline; Guillaumet, Gerald
Journal of Medicinal Chemistry, 1993 , vol. 36, # 4 p. 497 - 503
反应条件
1: 90 percent / Br2 / dimethylformamide / 2 h / Ambient temperature 2: 92 percent / 10percent NaOH / H2O / 8 h / Heating 3: 1.) P2O5, hexamethyldisiloxane / 1.) 1,2-dichloroethane, reflux, 2 h, 2.) 200 deg C, 3 h View Scheme
参考文献
Viaud, Marie-Claude; Jamoneau, Patricia; Savelon, Laurence; Guillaumet, Gerald
Heterocycles, 1995 , vol. 41, # 12 p. 2799 - 2810
反应条件
bromine in N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
METHYLGENE INC.
Patent: WO2009/100536 A1, 2009 ;
Location in patent: Page/Page column 95-96 ;
WO 2009/100536 A1
反应条件
1: Cl2 / dimethylformamide / Ambient temperature
2: H2O
3: SOCl2 / CHCl3
4: methanol / 0.13 h / Heating
View Scheme
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
