4'-溴苯并-15-冠5-醚合成路线 （共 10 条）
反应条件
bromine in tetrahydrofuran; 1,4-dioxane T=0°C;
参考文献
Kimura, Masaru; Shi, Kun; Hashimoto, Koji; Hu, Zhi Zhi
Heterocycles, 2006 , vol. 68, # 11 p. 2375 - 2380
反应条件
1: 52 percent / aq. NaOH / butan-1-ol / Heating 2: 80 percent / bromine / dioxane; tetrahydrofuran / 0 °C View Scheme
参考文献
Heterocycles, , vol. 68, # 11 p. 2375 - 2380
反应条件
1: 81 percent / SOCl2; pyridine / benzene / Heating 2: 52 percent / aq. NaOH / butan-1-ol / Heating 3: 80 percent / bromine / dioxane; tetrahydrofuran / 0 °C View Scheme
参考文献
Heterocycles, , vol. 68, # 11 p. 2375 - 2380
反应条件
1: 54 percent / dimethylsulfoxide / 8 h / Heating 2: 66 percent / ethanol; aq. KOH / 24 h / Heating View Scheme
参考文献
Fu, Enqin; Granell, Jaume; Green, Malcolm L.H.; Lowe, Valerie J.; Marder, Seth R.; et al.
Journal of Organometallic Chemistry, 1988 , vol. 355, p. 205 - 218
反应条件
hydrogenchloride; n-butyllithium 1.) ether-THF, -60 deg C; Yield given. Multistep reaction;
参考文献
Russian Chemical Bulletin, , vol. 42, # 5 p. 960 - 961
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 5 p. 996
反应条件
n-butyllithium 1) Et2O, THF, hexane, -60 deg C, 2.0 h; 2) DMF, Et2O, THF, hexane, -60 deg C, 4.0 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Russian Chemical Bulletin, , vol. 44, # 1 p. 116 - 123
Izvestiya Akademi Nauk, Seriya Khimicheskaya, , # 1 p. 121 - 128
反应条件
n-butyllithium 1) Et2O, THF, hexane, -60 deg C, 2.0 h; 2) Et2O, THF, hexane, -60 deg C, 4.0 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Russian Chemical Bulletin, , vol. 44, # 1 p. 116 - 123
Izvestiya Akademi Nauk, Seriya Khimicheskaya, , # 1 p. 121 - 128
反应条件
n-butyllithium 1) Et2O, THF, hexane, -60 deg C, 2.0 h; 2) DMF, Et2O, THF, hexane, -60 deg C, 4.0 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gromov, S. P.; Fedorova, O. A.; Vedernikov, A. I.; Samoshin, V. V.; Zefirov, N. S.; Alfimov, M. V.
Russian Chemical Bulletin, 1995 , vol. 44, # 1 p. 116 - 123
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 1995 , # 1 p. 121 - 128
反应条件
n-butyllithium 1) Et2O, THF, hexane, -60 deg C, 2.0 h; 2) Et2O, THF, hexane, -60 deg C, 4.0 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gromov, S. P.; Fedorova, O. A.; Vedernikov, A. I.; Samoshin, V. V.; Zefirov, N. S.; Alfimov, M. V.
Russian Chemical Bulletin, 1995 , vol. 44, # 1 p. 116 - 123
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 1995 , # 1 p. 121 - 128
反应条件
niobium bromide in benzonitrile
参考文献
Kal'chenko, V. I.; Atamas', L. I.; Parkhomenko, N. A.; Markovskii, L. N.
J. Gen. Chem. USSR (Engl. Transl.), 1990 , vol. 60, # 10.1 p. 2248 - 2256,2009 - 2015
