(6R,7R)-3-(乙酰氧基甲基)-8-氧代-7-[(2-氨基-4-噻唑基)(甲氧基亚胺)乙酰氨基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸合成路线 （共 3 条）
反应条件
sodium acetate in methanol; dichloromethane; water
参考文献
Gerlach, Benjamin; Ludescher, Johannes; Totschnig, Klaus
Patent: US2002/128469 A1, 2002 ;
反应条件
NaOAc·3H2O in water; acetone
参考文献
Biochemie Gesellschaft m.b.H.
Patent: US5831086 A1, 1998 ;
反应条件
<b>Multi-step reaction with 5 steps<br /> </b>1: ethanol; H<sub>2</sub>O / 1 h / 20 °C<br />2: thiourea / ethanol / 0.17 h / Heating<br />3: Et<sub>3</sub>N / dimethylformamide / 2 h<br />4: aq. NaOH / dioxane / 1 h / 30 °C<br />5: (i) ClCO<sub>2</sub>iBu, N-methylmorpholine, THF, CH<sub>2</sub>Cl<sub>2</sub>, (ii) /BRN= 622638/, Et<sub>3</sub>N, (iii) aq. HCO<sub>2</sub>H<br /> <br />
参考文献
Bucourt,R. et al. Tetrahedron, 1978 , vol. 34, p. 2233 - 2243
