3-(环丙基氧基)-4-羟基苯甲腈合成路线 （共 4 条）
反应条件
sodium methylate; lauryl mercaptan in N,N-dimethyl-formamide
T=100°C; 1 h;
参考文献
Frey, Lisa F.; Marcantonio, Karen M.; Chen, Cheng-Yi; Wallace, Debra J.; Murry, Jerry A.; Tan, Lushi; Chen, Weirong; Dolling, Ulf H.; Grabowski, Edward J. J.
Tetrahedron, 2003 , vol. 59, # 33 p. 6363 - 6373
反应条件
1.1: 17 percent / NaOMe; 1-dodecanethiol / dimethylformamide / 1 h / 100 °C
2.1: Cs2CO3; Triton X-405 / tetrahydrofuran / 5 h / 65 °C
2.2: t-BuOK / tetrahydrofuran / 1 h / -10 - 20 °C
3.1: 79 percent / ZnEt2; Cl3CCO2H / heptane; 1,2-dichloro-ethane / 17 h / -20 - 0 °C
4.1: 99 percent / NaOMe; 1-dodecanethiol / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
Frey, Lisa F.; Marcantonio, Karen M.; Chen, Cheng-Yi; Wallace, Debra J.; Murry, Jerry A.; Tan, Lushi; Chen, Weirong; Dolling, Ulf H.; Grabowski, Edward J. J.
Tetrahedron, 2003 , vol. 59, # 33 p. 6363 - 6373
反应条件
1.1: Cs2CO3; Triton X-405 / tetrahydrofuran / 5 h / 65 °C
1.2: t-BuOK / tetrahydrofuran / 1 h / -10 - 20 °C
2.1: 79 percent / ZnEt2; Cl3CCO2H / heptane; 1,2-dichloro-ethane / 17 h / -20 - 0 °C
3.1: 99 percent / NaOMe; 1-dodecanethiol / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
Frey, Lisa F.; Marcantonio, Karen M.; Chen, Cheng-Yi; Wallace, Debra J.; Murry, Jerry A.; Tan, Lushi; Chen, Weirong; Dolling, Ulf H.; Grabowski, Edward J. J.
Tetrahedron, 2003 , vol. 59, # 33 p. 6363 - 6373
反应条件
1: 79 percent / ZnEt2; Cl3CCO2H / heptane; 1,2-dichloro-ethane / 17 h / -20 - 0 °C
2: 99 percent / NaOMe; 1-dodecanethiol / dimethylformamide / 1 h / 100 °C
View Scheme
参考文献
Frey, Lisa F.; Marcantonio, Karen M.; Chen, Cheng-Yi; Wallace, Debra J.; Murry, Jerry A.; Tan, Lushi; Chen, Weirong; Dolling, Ulf H.; Grabowski, Edward J. J.
Tetrahedron, 2003 , vol. 59, # 33 p. 6363 - 6373
