六氢-1H-呋喃并[3,4-c]吡咯合成路线 （共 4 条）
反应条件
hydrogen; palladium(II) oxide hydrate in ethanol
T=20°C; 12 h;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00293 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 - 20 °C / |Inert atmosphere
2.1: p-toluenesulfonyl chloride; 4-(N,N-dimethlyamino)pyridine; triethylamine / toluene / 12 h / 20 °C / |Inert atmosphere
2.2: 4 h / |Reflux
3.1: hydrogen; palladium(II) oxide hydrate / ethanol / 12 h / 20 °C
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1.1: p-toluenesulfonyl chloride; 4-(N,N-dimethlyamino)pyridine; triethylamine / toluene / 12 h / 20 °C / |Inert atmosphere
1.2: 4 h / |Reflux
2.1: hydrogen; palladium(II) oxide hydrate / ethanol / 12 h / 20 °C
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
sodium hydroxide in water
参考文献
ICI United States Inc.
Patent: US3975532 A1, 1976 ;
