1-(3,4-二甲氧基苯基)-2-吡咯烷-2-基乙酮合成路线 （共 17 条）
反应条件
sodium tris(acetoxy)borohydride in tetrahydrofuran; acetic acid
T=0°C; 0.5 h;
参考文献
Couture; Deniau; Grandclaudon; Lebrun
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752
反应条件
caesium carbonate; thiophenol in acetonitrile
T=23°C; Inert atmosphere;
参考文献
Ambrosini, Lisa M.; Cernak, Tim A.; Lambert, Tristan H.
Tetrahedron, 2010 , vol. 66, # 26 p. 4882 - 4887
反应条件
sodium hydroxide in ethanol
1.25 h; Heating;
参考文献
Brown, Dearg S.; Charreau, Philippe; Hansson, Thomas; Ley, Steven V.
Tetrahedron, 1991 , vol. 47, # 7 p. 1311 - 1328
反应条件
diamine oxidase; catalase
T=27°C; 24 h; pH 7.0;
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
phosphate buffer in methanol; water
1 h;
参考文献
Mangla, V. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 9 p. 748 - 749
反应条件
1: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
2: 67 percent / aq. KOH / 40 h / Ambient temperature
3: 51 percent
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: 67 percent / aq. KOH / 40 h / Ambient temperature
2: 51 percent
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: 1.) sodium wire / 1) ether; 2) ether, reflux, 5 h
2: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
3: 67 percent / aq. KOH / 40 h / Ambient temperature
4: 51 percent
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: 95 percent / diethyl ether / 0.5 h / Irradiation
2: 91 percent / sodium triacetoxyborohydride / acetic acid; tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Couture; Deniau; Grandclaudon; Lebrun
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752
反应条件
1: 59 percent / 1.) BuLi / tetrahydrofuran / 1.) from -78 deg C to room temp.; 2.) from -30 deg C to room temp.
2: 95 percent / diethyl ether / 0.5 h / Irradiation
3: 91 percent / sodium triacetoxyborohydride / acetic acid; tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Couture; Deniau; Grandclaudon; Lebrun
Tetrahedron Letters, 1996 , vol. 37, # 43 p. 7749 - 7752
