1-(3,4-二甲氧基苯基)-2-吡咯烷-2-基乙酮合成路线 （共 17 条）
反应条件
1: 1) MgBr2*Et2O / 1) CH2Cl2, -78 deg C, 30 min, 2) 0 deg C, 7h
2: 80 percent / 3M aq. NaOH / ethanol / 1.25 h / Heating
View Scheme
参考文献
Brown, Dearg S.; Charreau, Philippe; Hansson, Thomas; Ley, Steven V.
Tetrahedron, 1991 , vol. 47, # 7 p. 1311 - 1328
反应条件
1: 80 percent / Et3N / diethyl ether / 2 h / Ambient temperature
2: 1) MgBr2*Et2O / 1) CH2Cl2, -78 deg C, 30 min, 2) 0 deg C, 7h
3: 80 percent / 3M aq. NaOH / ethanol / 1.25 h / Heating
View Scheme
参考文献
Brown, Dearg S.; Charreau, Philippe; Hansson, Thomas; Ley, Steven V.
Tetrahedron, 1991 , vol. 47, # 7 p. 1311 - 1328
反应条件
1: 98 percent / oxalyl chloride / benzene; dimethylformamide / 2 h / Ambient temperature
2: 1.) sodium wire / 1) ether; 2) ether, reflux, 5 h
3: 86 percent / sodium acetate / aq. ethanol / 6 h / Heating
4: 67 percent / aq. KOH / 40 h / Ambient temperature
5: 51 percent
View Scheme
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
反应条件
1: aq. KOH / 24 h / 20 °C
2: aq. phosphate buffer / 60 h / 20 °C / pH 7.0
View Scheme
参考文献
Sharma, Vedula M.; Adi Seshu; Vamsee Krishna; Prasanna; Chandra Sekhar; Venkateswarlu; Rajagopal, Sriram; Ajaykumar; Deevi, Dhanvanthri S.; Rao Mamidi; Rajagopalan
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1679 - 1682
反应条件
in methanol; phosphate buffer
pH=7;
参考文献
Kimball, F. Scott; Tunoori, Ashok Rao; Victory, Samuel F.; Dutta, Dinah; White, Jonathan M.; Himes, Richard H.; Georg, Gunda I.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4703 - 4707
参考文献
Cragg, John E.; Herbert, Richard B.; Jackson, Frederick B.; Moody, Christopher J.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2477 - 2486
参考文献
Bhakuni, Dewan S.; Mangla, Virendra K.
Tetrahedron, 1981 , vol. 37, p. 401 - 407
