(5-硝基吡啶-2-基)丙二酸二乙酯合成路线 （共 12 条）
反应条件
1.1: nitric acid / 15 h / Reflux 2.1: sulfuric acid / 5 h / Reflux 3.1: 1 h / Reflux 4.1: hydrogen / palladium 10 on activated carbon / acetic acid / 760.05 Torr 5.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 °C 5.2: 0.25 h 6.1: sodium t-butanolate / palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 2 h / 95 °C / Inert atmosphere 7.1: potassium hydroxide / Reflux View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
反应条件
1: sulfuric acid / water / |Reflux 2: iodine; 2-methyl-2-iodopropane; trifluoroacetic acid / dimethyl sulfoxide / 3 h / 170 °C View Scheme
参考文献
Mundinger, Stephan; Jakob, Uwe; Bichovski, Plamen; Bannwarth, Willi
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 8968 - 8979,12
反应条件
nitric acid 15 h; Reflux;
参考文献
PFIZER INC
Patent: US2011/111046 A1, 2011 ;
Location in patent: Page/Page column 15 ;
反应条件
1.1: sulfuric acid / Heating 2.1: UHP; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C 3.1: tetrahydrofuran / -60 °C / Inert atmosphere 3.2: -60 - 20 °C / Inert atmosphere 4.1: iron; acetic acid / 5 h / 110 °C 5.1: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme
参考文献
Organic Letters, , vol. 13, # 22 p. 6102 - 6105
反应条件
water; sodium chloride in dimethyl sulfoxide T=120°C; 2 h;
参考文献
WO2013/13815 A1, ;
Page/Page column 141; 142 ;
WO 2013/013815 A1
反应条件
1: nitric acid / 15 h / Reflux 2: sulfuric acid / 5 h / Reflux View Scheme
参考文献
PFIZER INC
Patent: US2011/111046 A1, 2011 ;
Title/Abstract Full Text Show Details
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
反应条件
sulfuric acid; water T=100°C; 2 h;
参考文献
F2G LTD
Patent: WO2008/62182 A1, 2008 ;
Location in patent: Page/Page column 117 ;
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran
T=20°C;
2: 2-chloro-5-nitro-pyridine in tetrahydrofuran
T=20°C; 24 h;
参考文献
DAISO CO., LTD.
Patent: EP1739077 A1, 2007 ;
Location in patent: Page/Page column 9 ;
反应条件
pyridine-2-carboxylic acid; copper(l) iodide; caesium carbonate in 1,4-dioxane
Reflux;
参考文献
Gruenenthal GmbH; FRANK, Robert; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo
Patent: US2013/29961 A1, 2013 ;
Location in patent: Paragraph 0696 ;
反应条件
1: trichlorophosphate; phosphorus pentachloride / 16 h / 60 °C
2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C
View Scheme
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard
Patent: WO2013/13815 A1, 2013 ;
WO 2013/013815 A1
