2,3-二氢-1-氧代-1H-茚-4-甲腈合成路线 （共 8 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1-methyl-pyrrolidin-2-one T=95°C; 7 h; Inert atmosphere;
参考文献
RECEPTOS, INC.; MARTINBOROUGH, Esther; BOEHM, Marcus, F.; YEAGER, Adam, Richard; TAMIYA, Junko; HUANG, Liming; BRAHMACHARY, Enugurthi; MOORJANI, Manisha
Patent: WO2011/60389 A1, 2011 ;
Location in patent: Page/Page column 87-88 ;
WO 2011/060389 A1
反应条件
in N-methyl-acetamide
参考文献
US5902803 A1, ;
US 5902803 A
反应条件
1: ethanol; iron (II)-sulfate; aqueous ammonia 2: aqueous hydrochloric acid; copper (II)-sulfate; water View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 139, p. 94
反应条件
1: carbon disulfide; AlCl3 2: ethanol; iron (II)-sulfate; aqueous ammonia 3: aqueous hydrochloric acid; copper (II)-sulfate; water View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 139, p. 94
反应条件
hydrogenchloride; water; copper(II) sulfate
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 139, p. 94
反应条件
1.1: ethanol; silica gel; sodium tetrahydroborate / 0 - 20 °C 2.1: potassium carbonate; hydroxylamine hydrochloride / ethanol / 16 h / Reflux 3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h / 20 °C 3.2: 1.08 h / 20 - 130 °C / Microwave irradiation 4.1: thionyl chloride; pyridine / dichloromethane / 0 - 20 °C 4.2: 48 h / 50 °C View Scheme
参考文献
THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2009/151529 A1, 2009 ;
WO 2009/151529 A1
反应条件
1: 66.6 percent / H2S, pyridine, Et3N / 19 h / 40 °C 2: CH2Cl2 / 16 h / Ambient temperature 3: NH4Cl / ethanol / 20 h / Heating 4: 72 percent / aq. HCl / H2O / 20 h / Ambient temperature View Scheme
参考文献
Stanek; Caravatti; Frei; Furet; Mett; Schneider; Regenass
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2168 - 2171
反应条件
1: titanium tetraethoxide / toluene / 12 h / 60 °C / Inert atmosphere 2: sodium tetrahydroborate; tetrahydrofuran / 2.5 h / -78 - 0 °C / Inert atmosphere 3: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C 4: sodium hydrogencarbonate / dichloromethane; water View Scheme
参考文献
RECEPTOS, INC.; MARTINBOROUGH, Esther; BOEHM, Marcus, F.; YEAGER, Adam, Richard; TAMIYA, Junko; HUANG, Liming; BRAHMACHARY, Enugurthi; MOORJANI, Manisha
Patent: WO2011/60389 A1, 2011 ;
WO 2011/060389 A1
