4-氨基-2,6-二溴苯酚合成路线 （共 23 条）
反应条件
pyridine in tetrahydrofuran
2 h;
参考文献
Johnson, Steven M.; Connelly, Stephen; Wilson, Ian A.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6348 - 6358
反应条件
1: 4-hydroxy-3,5-dibromoaniline With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C;
2: ethyl iodide in N,N-dimethyl-formamide
T=20°C; 72 h;
参考文献
KING'S COLLEGE LONDON; CORCORAN, Jonathan Patrick Thomas; KALINDJIAN, Sarkis Barret; BORTHWICK, Alan David; ADAMS, David Reginald; BROWN, Jane Theresa; TADDEI, David Michel Adrien; SHIERS, Jason, John
Patent: WO2011/27106 A1, 2011 ;
Location in patent: Page/Page column 83 ;
WO 2011/027106 A1
反应条件
2: potassium hydroxide; ethanol / Erhitzen des Reaktionsprodukts mit wss. Salzsaeure
View Scheme
参考文献
Bargellini
Gazzetta Chimica Italiana, 1930 , vol. 60, p. 559,569
