1: With triethylamine in acetonitrile
T=20°C; 4 h; Inert atmosphere;
2: With sodium hydroxide in diethyl ether; water
3: With hydrogenchloride in water
pH=2;
参考文献
AMGEN INC.
Patent: WO2009/151495 A2, 2009 ;
Location in patent: Page/Page column 54-55 ;
WO 2009/151495 A2
Beilin, V. G.; Kirillova, E. N.; Dashkevich, L. B.; Lebedev, A. A.; Malachevskaya, A. S.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 1 p. 14 - 17
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 1 p. 20 - 23