1: SOCl2 / 0.25 h / Heating 2: 70 percent / 12 h / Ambient temperature View Scheme
参考文献
Loppinet-Serani, Anne; Charbonnier, Florence; Rolando, Christian; Huc, Ivan
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 4 p. 937 - 942
1: sodium hypochlorite, 50percent aq. NaOH / Ambient temperature 2: SOCl2 / dimethylformamide / 2 h / Heating View Scheme
参考文献
Winn, Martin; De, Biswanath; Zydowsky, Thomas M.; Altenbach, Robert J.; Basha, Fatima Z.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2676 - 2688
potassium hydroxide in methanol; water 8.5 h; Heating;
参考文献
Masu, Hyuma; Ohmori, Ken; Kishikawa, Keiki; Yamamoto, Makoto; Yamaguchi, Kentaro; Kohmoto, Shigeo
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 6 p. 1127 - 1131
Gero, Thomas W.; Jaques, Larry W.; Mays, Richard P.; Reid, Debra H.; Shamblee, Dwight A.; et al.
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 553 - 560
1: 2-oxy-pyridine-3-carboxylic acid With sodium hydroxide; sodium chlorite in water T=0 - 20°C; 21 h; 2: With hydrogenchloride; sodium sulfite in water 3: methanol With thionyl chloride; sodium hydrogencarbonate more than 3 stages;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1726590 A1, 2006 ;
Location in patent: Page/Page column 82 ;
1: sodium hypochlorite, 50percent aq. NaOH / Ambient temperature 2: SOCl2 / dimethylformamide / 2 h / Heating View Scheme
参考文献
Winn, Martin; De, Biswanath; Zydowsky, Thomas M.; Altenbach, Robert J.; Basha, Fatima Z.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2676 - 2688
