反应条件
1.1: sodium bromide; sodium hydroxide; sodium hypochlorite / water / 1.5 h / 5 - 20 °C / |Large scale 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 7 h / 70 - 105 °C / |Large scale 3.1: sodium hydrogencarbonate / acetonitrile / 0.5 h / 25 °C / |Large scale 3.2: 22 h / 20 - 34 °C / |Large scale 4.1: tetrahydrofuran / 14.25 h / 5 - 90 °C / |Inert atmosphere; |Large scale 5.1: sodium hexamethyldisilazane / tetrahydrofuran / 4 h / 50 - 55 °C / |Inert atmosphere; |Large scale 6.1: tetrahydrofuran / 12 h / 25 - 30 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Busacca, Carl A.; Cerreta, Mike; Dong, Yong; Eriksson, Magnus C.; Farina, Vittorio; Feng, XuWu; Kim, Ji-Young; Lorenz, Jon C.; Sarvestani, Max; Simpson, Robert; Varsolona, Rieh; Vitous, Jana; Campbell, Scot J.; Davis, Mark S.; Jones, Paul-James; Norwood, Daniel; Qiu, Fenghe; Beaulieu, Pierre L.; Duceppe, Jean-Simon; Hache, Bruno; Brong, Jim; Chiu, Fang-Ting; Curtis, Tom; Kelley, Jason; Lo, Young S.; Powner, Tory H.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 603 - 613
