13-氢过氧基-9,11-十八碳二烯酸甲酯合成路线 （共 7 条）
反应条件
potassium hydroxide in methanol 0.0833333 h; Ambient temperature;
参考文献
Yamada; Murakami; Morimoto; Sakakibara
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 10 p. 1863 - 1865
反应条件
phosphorous acid trimethyl ester
参考文献
Okada, Youji; Tanaka, Kaoru; Sato, Eisuke; Okajima, Haruo
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 6 p. 1097 - 1102
反应条件
Fe(III)-peplomycin; oxygen multistep reaction: Fe(III)-peplomycin catalyzed oxygenation;
参考文献
Nagata, Ryu; Morimoto, Shinji; Saito, Isao
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4485 - 4488
反应条件
1: 100 percent / 5percent KOH / methanol / 0.08 h / Ambient temperature 2: 94 percent / NaBH4 / methanol / 0.17 h / Ambient temperature View Scheme
参考文献
Yamada; Murakami; Morimoto; Sakakibara
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 10 p. 1863 - 1865
反应条件
phosphorous acid trimethyl ester
参考文献
Okada, Youji; Tanaka, Kaoru; Sato, Eisuke; Okajima, Haruo
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 6 p. 1097 - 1102
反应条件
Fe(III)-peplomycin; oxygen
multistep reaction: Fe(III)-peplomycin catalyzed oxygenation;
参考文献
Nagata, Ryu; Morimoto, Shinji; Saito, Isao
Tetrahedron Letters, 1990 , vol. 31, # 31 p. 4485 - 4488
反应条件
1: 60 percent / Ac2O, DMAP / diethyl ether / 15 h / Ambient temperature
2: 1.) Co(tdcpp), O2, Et3SiH, 2.) trimethyl phosphite / 1.) i-PrOH, CH2Cl2, 1 atm, 28 deg C, 1 h, 2.) room temperature, 1 h
3: p-TsOH*H2O / benzene / 1 h / Heating
4: 94 percent / 2M NaOH / H2O; methanol / 1 h / Heating
View Scheme
参考文献
Hayashi, Yoshiki; Nishikawa, Yasushi; Mori, Hirotaka; Matsushita, Yoh-ichi; Sugamoto, Kazuhiro; Matsui, Takanao
Bioscience, Biotechnology, and Biochemistry, 1998 , vol. 62, # 9 p. 1771 - 1773
