7-羟基香豆素-3-羧酸乙酯合成路线 （共 24 条）
反应条件
sodium hydroxide 0.5 h; Heating;
参考文献
Lokhande, S. B.; Rangnekar, D. W.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 638 - 639
反应条件
1: sodium hydroxide; hydrogenchloride; water 2: 12 h / |Reflux View Scheme
参考文献
Liu, Jinbing; Wu, Fengyan; Chen, Lingjuan; Zhao, Liangzhong; Zhao, Zibing; Wang, Min; Lei, Sulan
Food Chemistry, 2012 , vol. 135, # 4 p. 2872 - 2878
反应条件
1: methanol. KOH-solution / Behandeln des Reaktionsprodukts mit wss. Alkalilauge 2: copper-powder / 240 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 74, p. 2692
参考文献
Boehm
Archiv der Pharmazie (Weinheim, Germany), 1933 , vol. 271, p. 490,502
Full Text Show Details
Shah; Shah
Journal of Organic Chemistry, 1954 , vol. 13, p. 1681,1685
反应条件
1: potassium carbonate, / dimethylformamide / 20 h / 100 °C 2: 10percent akoholic potassium hydroxyde View Scheme
参考文献
Thaker, N. N.; Trivedi, K. N.
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1981 , vol. 20, # 6 p. 560 - 563
反应条件
piperidine
T=20°C; Knoevenagel condensation; 2 h;
参考文献
Vieira, Lucas C.C.; Paixao, Marcio Weber; Correa, Arlene G.
Tetrahedron Letters, 2012 , vol. 53, # 22 p. 2715 - 2718
参考文献
Dawson, Marcia J.; Fontana, Joseph A.; Zhang, Xiao-kun; Leid, Mark; Jong, Ling; Hobbs, Peter D.
Patent: US2003/176506 A1, 2003 ;
反应条件
1: 2,4-dihydroxy-benzaldehyde With 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=22°C; 168 h; Inert atmosphereCooling;
2: diethyl malonate With morpholine; acetic acid in methanol
Inert atmosphereCoolingHeating;
参考文献
3M INNOVATIVE PROPERTIES COMPANY; ROSCOE, Stephen, B.; CHOU, Shih-Hung; MOELLER, Stephanie, J.; MILLER, Jesse, D.; HALVERSON, Kurt, J.; BJORK, Jason, W.
Patent: WO2012/134724 A1, 2012 ;
Location in patent: Page/Page column 36-38 ;
反应条件
1: With sodium hydrogencarbonate in water
T=20°C; 16 h;
2: With hydrogenchloride in water
T=90°C; 7 h;
参考文献
Fringuelli, Francesco; Girotti, Rugiada; Pizzo, Ferdinando; Zunino, Ennio; Vaccaro, Luigi
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 3 p. 297 - 300
反应条件
titanium tetrachloride in tetrahydrofuran
Heating;
参考文献
Bissell
Synthesis, 1982 , vol. No. 10, p. 846 - 848
