反应条件
1.1: (COCl)2; DMF / toluene / 4 h / 20 °C
2.1: KHMDS / tetrahydrofuran; toluene / 1 h / -78 °C
2.2: tetrahydrofuran; toluene / 1 h / -78 °C
3.1: 106 g / 4-acetoamidobenzenesulfonyl azide; Et3N / acetonitrile / 2 h / 20 °C
4.1: 82 percent / Rh2(OAc)4*H2O / various solvent(s) / 0.5 h / 60 °C
5.1: 100 percent / H2O; dimethylsulfoxide / 1 h / 150 °C
View Scheme
参考文献
Watanabe, Nobuhide; Ikeno, Akihisa; Minato, Hisao; Nakagawa, Hiroshi; Kohayakawa, Chie; Tsuji, Jun-Ichi
Journal of Medicinal Chemistry, 2003 , vol. 46, # 19 p. 3961 - 3964
