2-溴-1,3-二甲基-4-硝基苯合成路线 （共 8 条）
反应条件
1: With triethyl amine hydrochloride; zinc in N,N-dimethyl-formamide T=80°C; 4 h; 2: With sodium hydroxide in water; N,N-dimethyl-formamide
参考文献
ENCYSIVE PHARMACEUTICALS INC.
Patent: WO2009/44311 A1, 2009 ;
Location in patent: Page/Page column 42-43 ;
WO 2009/044311 A1
反应条件
sulfuric acid; nitric acid
T=-10°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 170 ;
WO 2013/026914 A1
反应条件
hydrogen; platinum(IV) oxide
参考文献
Wu, Chengde; Anderson, C. Eric; Bui, Huong; Gao, Daxin; Kassir, Jamal; Li, Wen; Wang, Junmei; Biediger, Ronald; Chen, Jie; Market, Robert V.
Patent: US2005/49286 A1, 2005 ;
US 20050049286 A1
反应条件
1: With triethyl amine hydrochloride; zinc in N,N-dimethyl-formamide
T=80°C; 4 h;
2: With sodium hydroxide in water; N,N-dimethyl-formamide
参考文献
ENCYSIVE PHARMACEUTICALS INC.
Patent: WO2009/44311 A1, 2009 ;
Location in patent: Page/Page column 42-43 ;
WO 2009/044311 A1
反应条件
1: in N,N-dimethyl-formamide
T=125°C; 5 h;
2: With zinc in water; acetic acid
T=0 - 110°C; 5 h;
参考文献
NEUROGEN CORPORATION
Patent: WO2005/110991 A1, 2005 ;
Location in patent: Page/Page column 50-51 ;
WO 2005/110991 A1
反应条件
1: With pyrrolidine in 1,4-dioxane
T=100°C; 18 h; Inert atmosphere;
2: With iron; acetic acid
T=110°C; 4 h;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 170 ;
WO 2013/026914 A1
反应条件
1: in DMF (N,N-dimethyl-formamide)
T=120 - 125°C; 5 h; Heating / reflux;
2: With acetic acid; zinc in water
T=0 - 110°C; 4 h; Heating / reflux;
参考文献
NEUROGEN CORPORATION
Patent: WO2004/43925 A2, 2004 ;
Location in patent: Page 68 ;
反应条件
1: pyrrolidine / N,N-dimethyl acetamide / 120 °C / |Sealed tube
2: acetic acid; zinc / water / 0 - 110 °C
View Scheme
参考文献
SAREUM LIMITED; READER, John Charles
Patent: WO2013/117522 A1, 2013 ;
