1-苄基-2-甲基-2-咪唑啉合成路线 （共 10 条）
反应条件
1: 1-benzyl-4,5-dihydroimidazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C; 4 h;
参考文献
Jones, Raymond C.F.; Nichols, John R.
Tetrahedron, 2013 , vol. 69, # 20 p. 4114 - 4119
反应条件
1: 1-benzyl-4,5-dihydroimidazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h; Inert atmosphere;
2: dimethyl sulfate in tetrahydrofuran; hexane
T=-78 - 20°C; 4 h;
参考文献
Jones, Raymond C.F.; Nichols, John R.
Tetrahedron, 2013 , vol. 69, # 20 p. 4114 - 4119
反应条件
potassium tert-butylate in ethanol
T=25°C; dealkoxycarbonylation; 168 h;
参考文献
Jones, Raymond C. F.; Patel, Pravin; Hirst, Simon C.; Turner, Ian
Tetrahedron, 1997 , vol. 53, # 34 p. 11781 - 11790
反应条件
sodium hydroxide; tetrabutylammomium bromide; potassium carbonate
T=20°C; Solid phase reaction; 2 h;
参考文献
Chen, Xu; Wang, Xiaolun; Wang, Hui; Lian, Hongzhen; Pan, Yi; Shi, Yaozeng
Synthetic Communications, 1999 , vol. 29, # 17 p. 3025 - 3030
反应条件
1: ethanol / 3 h / Heating
2: 35 g / 30percent aq. sodium hydroxide
View Scheme
参考文献
Anderson, Michael W.; Begley, Michael J.; Jones, Raymond C. F.; Saunders, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 11 p. 2599 - 2602
参考文献
Kyrides et al.
Journal of Organic Chemistry, 1947 , vol. 12, p. 577,582
参考文献
Anderson, Michael W.; Begley, Michael J.; Jones, Raymond C. F.; Saunders, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 11 p. 2599 - 2602
参考文献
Anderson; Jones; Saunders
Tetrahedron Letters, 1981 , vol. 22, # 3 p. 261 - 264
参考文献
Organon Inc.
Patent: US2813862 , 1954 ;
反应条件
in toluene
2 h; Heatingor heating under reduced pressure; Product distributionMechanism;
参考文献
Jones, Raymond C. F.; Anderson, Michael W.; Smallridge, Mark J.
Tetrahedron Letters, 1988 , vol. 29, # 39 p. 5001 - 5004
