phosphate buffer in ethanol T=48°C; 2.5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

1: 80 percent / pyridine / 0.75 h / Ambient temperature 2: 0.1 M phosphate buffer (pH=7.8) / aq. ethanol / 2.5 h / 48 °C View Scheme

1: NO2/HNO3 / acetic acid 2: NO2/HNO3 3: aq. HBr / acetic acid 4: aq. N2H4 / bis-(2-hydroxy-ethyl) ether 5: benzene 6: (i) NO2/HNO3, HNO3, (ii) aq. HBr, AcOH 7: aq. NaOH / ethanol 8: (i) aq. HCl, NaNO2, (ii) H3PO2 9: (i) N2H4, Pd-C, (ii) /BRN= 385737/ View Scheme

1: NO2/HNO3 2: aq. HBr / acetic acid 3: aq. N2H4 / bis-(2-hydroxy-ethyl) ether 4: benzene 5: (i) NO2/HNO3, HNO3, (ii) aq. HBr, AcOH 6: aq. NaOH / ethanol 7: (i) aq. HCl, NaNO2, (ii) H3PO2 8: (i) N2H4, Pd-C, (ii) /BRN= 385737/ View Scheme

1: (i) NaOH, EtOH, (ii) /BRN= 969135/ 2: NO2/HNO3 / acetic acid 3: NO2/HNO3 4: aq. HBr / acetic acid 5: aq. N2H4 / bis-(2-hydroxy-ethyl) ether 6: benzene 7: (i) NO2/HNO3, HNO3, (ii) aq. HBr, AcOH 8: aq. NaOH / ethanol 9: (i) aq. HCl, NaNO2, (ii) H3PO2 10: (i) N2H4, Pd-C, (ii) /BRN= 385737/ View Scheme

1: (i) NaNO2, aq. HBF4, (ii) /BRN= 3596974/, benzene, H2O 2: (i) NaOH, EtOH, (ii) /BRN= 969135/ 3: NO2/HNO3 / acetic acid 4: NO2/HNO3 5: aq. HBr / acetic acid 6: aq. N2H4 / bis-(2-hydroxy-ethyl) ether 7: benzene 8: (i) NO2/HNO3, HNO3, (ii) aq. HBr, AcOH 9: aq. NaOH / ethanol 10: (i) aq. HCl, NaNO2, (ii) H3PO2 11: (i) N2H4, Pd-C, (ii) /BRN= 385737/ View Scheme

1: (i) aq. HCl, NaNO2, (ii) H3PO2 2: (i) N2H4, Pd-C, (ii) /BRN= 385737/ View Scheme

(i) N2H4, Pd-C, (ii) /BRN= 385737/; Multistep reaction;