5-(3-碘苯基)异噁唑-3-羧酸甲酯合成路线 （共 3 条）
反应条件
hydroxylamine hydrochloride in methanol
4 h; Heating / reflux;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259860 A1, 2007 ;
Location in patent: Page/Page column 16-17 ;
US 20070259860 A1
反应条件
1: With methanol; sodium methylate
T=20°C; 16 h;
2: With hydroxylamine hydrochloride; toluene-4-sulfonic acid in methanol
72 h; Heating;
参考文献
Liu, Gang; Xin, Zhili; Pei, Zhonghua; Hajduk, Philip J.; Abad-Zapatero, Cele; Hutchins, Charles W.; Zhao, Hongyu; Lubben, Thomas H.; Ballaron, Stephen J.; Haasch, Deanna L.; Kaszubska, Wiweka; Rondinone, Cristina M.; Trevillyan, James M.; Jirousek, Michael R.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 20 p. 4232 - 4235
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=80°C; 0.166667 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS, INC.
Patent: US2007/259860 A1, 2007 ;
Location in patent: Page/Page column 17 ;
US 20070259860 A1
