N,5-二甲基-3-苯基-异噁唑-4-羧酰胺合成路线 （共 4 条）
反应条件
1: 5-Methyl-3-phenyl-isoxazole-4-carboxylic acid With thionyl chloride; N,N-dimethyl-formamide in 1,2-dichloro-ethane
2 h; Heating / reflux;
2: methylamine in ethanol; 1,2-dichloro-ethane
T=5°C;
参考文献
NOVARTIS AG
Patent: JP2005/501847 A, 2005 ;
Location in patent: Page/Page column 9 ;
反应条件
1: SOCl2 / 1,2-dichloro-ethane / 2 h / 80 °C
2: ethanol / 12 h / 0 - 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
in ethanol
T=0 - 20°C; 12 h;
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
1.2: tetrahydrofuran; hexane / -70 - 20 °C
2.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
