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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
氯呋酸
合成路线
(共 7 条)
60987-05-5
→
反应条件
60986-89-2
氯呋酸
反应条件
toluene-4-sulfonic acid in toluene 3 h; Heating;
参考文献
Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471
57568-39-5
→
反应条件
60986-89-2
氯呋酸
反应条件
1: 75 percent / KOH, H2O / ethanol / 20 h / Heating 2: HCl(g) / 0.5 h 3: SOCl2 / CH2Cl2 / Ambient temperature 4: BBr3 / CH2Cl2 / 1 h / Ambient temperature 5: 2 N ethanol. NaOH / 4 h / Ambient temperature 6: p-toluenesulfonic acid / toluene / 3 h / Heating View Scheme
参考文献
Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471
57568-38-4
→
反应条件
60986-89-2
氯呋酸
反应条件
1: 91 percent / S / 6 h / Heating 2: 75 percent / KOH, H2O / ethanol / 20 h / Heating 3: HCl(g) / 0.5 h 4: SOCl2 / CH2Cl2 / Ambient temperature 5: BBr3 / CH2Cl2 / 1 h / Ambient temperature 6: 2 N ethanol. NaOH / 4 h / Ambient temperature 7: p-toluenesulfonic acid / toluene / 3 h / Heating View Scheme
参考文献
Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471
41876-58-8
→
反应条件
60986-89-2
氯呋酸
反应条件
1: 69 percent / SnCl4 / CH2Cl2 / 20 h / Ambient temperature 2: 91 percent / S / 6 h / Heating 3: 75 percent / KOH, H2O / ethanol / 20 h / Heating 4: HCl(g) / 0.5 h 5: SOCl2 / CH2Cl2 / Ambient temperature 6: BBr3 / CH2Cl2 / 1 h / Ambient temperature 7: 2 N ethanol. NaOH / 4 h / Ambient temperature 8: p-toluenesulfonic acid / toluene / 3 h / Heating View Scheme
参考文献
Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471
57568-40-8
→
反应条件
60986-89-2
氯呋酸
反应条件
1: HCl(g) / 0.5 h 2: SOCl2 / CH2Cl2 / Ambient temperature 3: BBr3 / CH2Cl2 / 1 h / Ambient temperature 4: 2 N ethanol. NaOH / 4 h / Ambient temperature 5: p-toluenesulfonic acid / toluene / 3 h / Heating View Scheme
参考文献
Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471
79380-74-8
→
反应条件
60986-89-2
氯呋酸
反应条件
1: SOCl2 / CH2Cl2 / Ambient temperature 2: BBr3 / CH2Cl2 / 1 h / Ambient temperature 3: 2 N ethanol. NaOH / 4 h / Ambient temperature 4: p-toluenesulfonic acid / toluene / 3 h / Heating View Scheme
参考文献
Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471
79380-76-0
→
反应条件
60986-89-2
氯呋酸
反应条件
1: BBr3 / CH2Cl2 / 1 h / Ambient temperature 2: 2 N ethanol. NaOH / 4 h / Ambient temperature 3: p-toluenesulfonic acid / toluene / 3 h / Heating View Scheme
参考文献
Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471