N(omega)-甲基色胺合成路线 （共 28 条）
反应条件
sulfuric acid; acetaldehyde
参考文献
Barger et al.
Recueil des Travaux Chimiques des Pays-Bas, 1938 , vol. 57, p. 548,553
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Juraschewskii et al.
Zhurnal Obshchei Khimii, 1941 , vol. 11, p. 157,161
Chem.Abstr., 1941 , p. 5503
反应条件
1: DMSO, 37percent HCl / 80 °C
2: AcOH / 3 h / Heating
View Scheme
参考文献
Bascop, Sophie-Isabelle; Sapi, Janos; Laronze, Jean-Yves; Levy, Jean
Heterocycles, 1994 , vol. 38, # 4 p. 725 - 732
反应条件
diethyl ether
Erwaermen des Reaktionsprodukts mit CH3I;
参考文献
Hoshino; Kobayashi
Justus Liebigs Annalen der Chemie, 1935 , vol. 520, p. 11,17
反应条件
1.1: acetic anhydride / 1 h / 60 °C
1.2: 90 percent / CH2Cl2 / 1.5 h / 20 °C
2.1: t-BuOCl; triethylamine / tetrahydrofuran / 0.5 h / -78 °C
2.2: tetrahydrofuran / 1.5 h / -78 - 20 °C
2.3: H2O2; NaOH / tetrahydrofuran; H2O / 1 h / 20 °C
3.1: 61 percent / N-bromosuccinimide; acetic acid; formic acid / 0.5 h / 20 °C
4.1: NaOH / ethanol / 24 h / Heating
View Scheme
参考文献
Lindel, Thomas; Braeuchle, Laura; Golz, Gregor; Boehrer, Petra
Organic Letters, 2007 , vol. 9, # 2 p. 283 - 286
反应条件
aluminium trichloride; triethylamine
1) CH2Cl2, pyridine, 3 h, reflux, 2) 3 h, reflux; Yield given. Multistep reaction;
参考文献
Bracher; Hildebrand
Pharmazie, 1993 , vol. 48, # 9 p. 695 - 695
反应条件
triethylamine in chloroform
T=20°C; 23 h;
参考文献
Somei; Yamada; Kurauchi; Nagahama; Hasegawa; Teranishi; Sato; Kaneko
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 87 - 96
反应条件
1: formic acid With acetic anhydride
T=60°C; 1 h;
2: [2-(1H-indol-3-yl)-ethyl]-methyl-amine in dichloromethane
T=20°C; 1.5 h;
参考文献
Lindel, Thomas; Braeuchle, Laura; Golz, Gregor; Boehrer, Petra
Organic Letters, 2007 , vol. 9, # 2 p. 283 - 286
反应条件
in diethyl ether
from 0 deg C up to r.t.;
参考文献
Mahboobi; Grothus; Meindl
Archiv der Pharmazie, 1994 , vol. 327, # 2 p. 105 - 114
