4-氨基-2-硝基苯甲酸合成路线 （共 26 条）
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 76, p. 287
参考文献
American Chemical Journal, , vol. 44, p. 448
反应条件
1: aq. HBr, NaNO2 / 0 °C 2: CuBr, aq. HBr / 0 °C 3: 62 percent / (NH4)2Fe(SO4)2, NH4OH / H2O / 0.03 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 5 p. 1240 - 1256
反应条件
sodium nitrite; copper(I) bromide in water; hydrogen bromide
参考文献
Chiron Corporation
Patent: US2005/261307 A1, 2005 ;
反应条件
1: aq. HBr, NaNO2 / 0 °C 2: CuBr, aq. HBr / 0 °C View Scheme
参考文献
CHIRON CORPORATION
Patent: WO2004/18419 A2, 2004 ;
Location in patent: Page 320-321 ;
参考文献
Wheeler; Johns
American Chemical Journal, 1910 , vol. 44, p. 448
反应条件
1: With sulfuric acid; sodium nitrite in water T=0 - 5°C; 1.25 h; 2: With urea in water T=0°C; 0.166667 h; 3: With sulfuric acid in water 3 h; Reflux;
参考文献
WYETH
Patent: US2005/70584 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
sodium nitrite in sulfuric acid
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US6608067 B1, 2003 ;
US 6608067 B1
反应条件
1: aqueous sulfuric acid 2: sulfuric acid View Scheme
参考文献
Drain et al.
Journal of the Chemical Society, 1949 , p. 1498,1502
反应条件
Ki; sodium nitrite in water
参考文献
Hoffmann-La Roche Inc.
Patent: US5753679 A1, 1998 ;
