3-硝基-4-甲氧基苄溴合成路线 （共 15 条）
反应条件
1: in methanol 4 h; Heating / reflux; 2: With hydrogenchloride; water in methanol T=0°C;
参考文献
ONCONOVA THERAPEUTICS, INC.
Patent: WO2008/33475 A2, 2008 ;
Location in patent: Page/Page column 53 ;
反应条件
1: sodium carbonate / methanol / 1 h / Reflux 2: dihydrogen peroxide / acetic acid / 6 h / 50 °C View Scheme
参考文献
Reddy, M. V. Ramana; Akula, Balireddy; Cosenza, Stephen C.; Athuluridivakar, Saikrishna; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Billa, Vinay K.; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Vasquez-Del Carpio, Rodrigo; Padgaonkar, Amol; Baker, Stacey J.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 578 - 599
反应条件
1: CH2Cl2 / Heating
2: sodium hydride / CH2Cl2 / 0 - 20 °C
3: sodium dithionite / acetone; H2O / 50 °C
View Scheme
参考文献
Pinney, Kevin G.; Mejia, Maria P.; Villalobos, Victor M.; Rosenquist, Brent E.; Pettit, George R.; Verdier-Pinard, Pascal; Hamel, Ernest
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 10 p. 2417 - 2425
反应条件
in ethanol
T=20°C; 1.5 h;
参考文献
CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria
Patent: WO2013/45280 A1, 2013 ;
Location in patent: Page/Page column 95 ;
反应条件
1: sodium carbonate / methanol / 1 h / Reflux
2: dihydrogen peroxide / acetic acid / 6 h / 50 °C
3: piperidine / pyridine / 36 h / 20 °C
5: sodium acetate
6: water; sodium carbonate
View Scheme
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
