4-(1-甲基乙基)哌嗪-1-甲酸乙酯合成路线 （共 6 条）
反应条件
hydrogen bromide 3 h; Heating;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
1: 90 percent / 45 percent HBr / 3 h / Heating 2: K2CO3 / acetonitrile View Scheme
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate in methanol (MeOH); H2 CCl2; acetone
参考文献
Schering Corporation
Patent: US5039676 A1, 1991 ;
反应条件
potassium carbonate in acetonitrile
24 h; Heating;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
p-toluenesulfonic acid,1-methylethyl ester; sodium carbonate; isopropyl alcohol
参考文献
Stewart et al.
Journal of Organic Chemistry, 1948 , vol. 13, p. 134,138
Full Text Show Details
Am. Cyanamid Co.
Patent: US2467895 , 1949 ;
DRP/DRBP Org.Chem.
Full Text Show Details
Am. Cyanamid Co.
Patent: DE844744 , 1951 ;
反应条件
1: 90 percent / 45 percent HBr / 3 h / Heating
2: K2CO3 / acetonitrile
3: LiAlH4 / diethyl ether
View Scheme
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
