2-氨基-5-(4-氟苯基)噻吩-3-羧酰胺合成路线 （共 4 条）
反应条件
sulfur; triethylamine in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Podolin, Patricia L.; Callahan, James F.; Bolognese, Brian J.; Li, Yue H.; Carlson, Karey; Davis, T. Gregg; Mellor, Geoff W.; Evans, Christopher; Roshak, Amy K.
Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 312, # 1 p. 373 - 381
反应条件
1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran
2: N-iodo-succinimide / dichloromethane
3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethylene glycol dimethyl ether; water / 100 °C
4: palladium on activated charcoal; hydrogen / ethanol / 80 °C
View Scheme
参考文献
Haidle, Andrew M.; Zabierek, Anna A.; Childers, Kaleen K.; Rosenstein, Craig; Mathur, Anjili; Altman, Michael D.; Chan, Grace; Xu, Lin; Bachman, Eric; Mo, Jan-Rung; Bouthillette, Melaney; Rush, Thomas; Tempest, Paul; Marshall, C. Gary; Young, Jonathan R.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1968 - 1973
反应条件
1: N-iodo-succinimide / dichloromethane
2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethylene glycol dimethyl ether; water / 100 °C
3: palladium on activated charcoal; hydrogen / ethanol / 80 °C
View Scheme
参考文献
Haidle, Andrew M.; Zabierek, Anna A.; Childers, Kaleen K.; Rosenstein, Craig; Mathur, Anjili; Altman, Michael D.; Chan, Grace; Xu, Lin; Bachman, Eric; Mo, Jan-Rung; Bouthillette, Melaney; Rush, Thomas; Tempest, Paul; Marshall, C. Gary; Young, Jonathan R.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1968 - 1973
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethylene glycol dimethyl ether; water / 100 °C
2: palladium on activated charcoal; hydrogen / ethanol / 80 °C
View Scheme
参考文献
Haidle, Andrew M.; Zabierek, Anna A.; Childers, Kaleen K.; Rosenstein, Craig; Mathur, Anjili; Altman, Michael D.; Chan, Grace; Xu, Lin; Bachman, Eric; Mo, Jan-Rung; Bouthillette, Melaney; Rush, Thomas; Tempest, Paul; Marshall, C. Gary; Young, Jonathan R.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1968 - 1973
