4-氨基-5-(4-氟苯基)-2,4-二氢-3H-1,2,4-三唑-3-硫酮合成路线 （共 6 条）
反应条件
1: With potassium hydroxide in ethanol T=20°C; 12 h; 2: With hydrazine hydrate in water 6 h; Reflux; 3: With hydrogenchloride in water Cooling;
参考文献
Cheeseright, Timothy J.; Holm, Melanie; Lehmann, Frank; Luik, Sabine; Gottert, Marcia; Melville, James L.; Laufer, Stefan
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4200 - 4209
反应条件
hydrazine hydrate in ethanol; water T=90°C; 2 h;
参考文献
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 79, # 5 p. 1837 - 1842
反应条件
hydrazine hydrate T=150 - 160°C;
参考文献
Nadkarni; Kamat; Khadse
Arzneimittel-Forschung/Drug Research, 2001 , vol. 51, # 7 p. 569 - 573
反应条件
1: 64.3 percent / hydrazine hydrate / ethanol / Heating 2: 76.92 percent / KOH / ethanol 3: 36.5 percent / hydrazine hydrate / 150 - 160 °C View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 51, # 7 p. 569 - 573
反应条件
1: sulfuric acid 2: hydrazine hydrate 3: ammonia / ethanol; water / 0 - 20 °C 4: hydrazine hydrate / ethanol; water / 2 h / 90 °C View Scheme
参考文献
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 79, # 5 p. 1837 - 1842
反应条件
1: 76.92 percent / KOH / ethanol 2: 36.5 percent / hydrazine hydrate / 150 - 160 °C View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 51, # 7 p. 569 - 573
